Anaphylactic and or Anaphylaxis shock in Homoeopathy.

In the early years of my practice when I don't have much experience I in the year 1974 only four years of experience I took up the case of a child suffering from Cirrhosis of the liver.It had developed ascites , slight jaundice and was in a bad condition. I did not offer my hope but, the parents wanted to try Homoeopathy as a last resort.I study case v carefully and study pointed to China. One dose of China 200 was given. There was a much improvement, the ascites went down urine became profuse . This improvement stopped after ten days.On the 11 the day there was slightly increase of the troubles. Next day it was worse. I examination the child carefully, heart and lungs were not bad but the ascites was increasing and urine was again less . The symptoms still points to China. So one more dose 200 the was given in the morning. At midday the child simply collapsed and was dead before they could do anything.i wondred how the child died so suddenly.
About one year later , I was asked to treat a case of dropy in a man aged about 52 years ,he was extremely fat ,but how much was fluid I could not say . His heart kidney and liver were not functioning well. Below the eyes were bag like sweelins . Complaint worse in the after noon 3 pm especially, and after sleep ,or rather after what little sleep ,he managed to snatch from time to time. He was averse to covering, wanted sips of ice cold water and fresh air . The scanty urine was loaded with albumin .
Apis 200 was given a single powder dry on the tounge, here again improved v nicely for about a week and symptoms started coming back again. On the tenth day morning Apis 200 was repeated one powder , from that time he suddenly became worse and urine practically stopped. The family called a senior Homoeopathic physician who have Lycopodium 200 . That was the last straw and he died without passing a single drop of urine after that.
These two cases set me thinking, why was the second dose so fatal ? I started studying the literature regarding this point.
Then a third chance came to verify this, by which time I was on the alert.
A girl 18 , puberty five years previously, now ill , emaciating no menses for four or five months, had slight cough , poor appetite, anameic condition and so on . Cough worse at 3 am Kali carb 1 m was given one single dose of 5 pills dry on the tounge. Cough better from that day , patient improving nicely for about 10 days . Then the symptoms started coming back.I was about to repeat , but the fear of some untowards happening made me hesitate. Ultimately on the 13 the day I gave her one dose of Kali carb 1 m potency dry on the tounge.. She rapidly became worse and in two days started getting fever , luckily one or two antidotes of Kali carb and finally Nat Mur 1 m not only saved her but also cured her . She got back her menses regularly put on her weight and later was happily married and continued healthy .
These experiences pose a problem, why does the second dose produced such violent reaction,and especially if given after ten days? To get a proper answer to this, I have searched among the clinical cases in our literature. Unfortunately, it must be admitted that drs, do not usually like to report what might be considered to be failures . So cases of the type are not found in numbers.
Hahnemann, our master, gave his options as follows
It is impractical to repeat the same unchanged dose of the remedy once , not to mention its frequent repetition ( and at short intervals, in order not to delay the cure ) . The vital principal does not accept such unchanged doses without resistance that is , without other symptoms of the medicine to manifest themselves than those similar to the disease to be cured ( organon 5th edition)  he advised that the Potency should be altered slightly every time remedy is repeated. But he did not mention anything about the time lag required to produce the oversensitive state that iam referring to.
Dr. Kent writes as follows if the first dose of medicine produces no effect and enough time has been allowed to be sure that the prover is not sensitive to it . Those who have been poisoned by Rhus tox are dozen times more sensitive than before .Those who have been poisoned by ARS are extremely sensitive to ARS after they allow the first effects to pass off . If they continue, however to keep on with the first effects, they become less sensitive to it, so that they require larger and larger doses to take effect.( Philosophy, page 219)
In my practice, I stopped using single dose for any case . Instead I have been giving on the first day two or three doses , at intervals of three or four hrs followed by placebo , if necessary, from the next day . Kent and others also used this method, which is single collective dose . I have never seen any upset by subsequent repetition insuch cases and I find this is an absolutely safe method.
I have mentioned Hahnemann's advice in his sixth edition of Organon to change the dose slightly every time the medicine is repeated. This method, also called plus Dosage, allows the same remedy to be repeated daily if necessary, even in chronic cases , so that the time taken for a cure is considerably reduced. This avoids also any severe aggravation or anaphylactic shock by the repetition .